Every contamination situation is unique, requiring customized approaches based on specific site conditions and contamination characteristics. The same mold species behaves differently in a basement versus an office building, while lead paint removal in a school requires different safety measures than in a vacant warehouse. Asbestos abatement protocols must account for building occupancy, material friability, and site-specific access limitations. Generic approaches create inadequate containment that allows contamination to spread, unnecessary work that inflates project costs without improving outcomes, safety gaps that expose workers and occupants to health risks, and incomplete remediation that allows problems to return. Site-specific protocols address unique challenges while ensuring complete and safe remediation.