Protocol development requires comprehensive analysis of contamination assessment data to determine removal methods and safety requirements based on the type, extent, and concentration of contaminants present. Building characteristics influence containment strategies and work procedures based on HVAC systems, occupancy patterns, and structural features that affect how contamination spreads. Regulatory requirements establish minimum standards for worker protection and environmental compliance through federal, state, and local regulations. Site-specific factors shape project logistics and safety protocols based on access limitations, utilities, and operational constraints. Each factor must be carefully evaluated to create protocols that ensure complete remediation while maintaining safety and cost-effectiveness.